it's been suggested that switching from multimeric to monomeric types of MIF, exposes a hydrophobic surface area that can provide chaperone action for misfolded mutant SOD1 [73]. The conversation amongst MIF and misfolded SOD1 is once again impartial of its tautomerase and oxidoreductase action as similar chaperone action was discovered using MIF mutants lacking tautomerase or oxidoreductase action [75]. On top of that, MIFN110C, a cysteine mutant of MIF and not able to induce CD74-dependent signaling, confirmed potent inhibition of misfolded SOD1 and higher affinity for SOD1 as compared to wildtype MIF [seventy five]. This acquiring indicates that the chaperone action of MIF is impartial of its CD74-mediated cytokine activity. Interactions of D-DT with SOD1 have not been analyzed however.
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